Cancer as Multifaceted Disease

Dogs as Disease and Cancer Detectors: A Literature Review

Cancer heterogeneity--a multifaceted view.

Cancers of various organs have been categorized into distinct subtypes after increasingly sophisticated taxonomies. Additionally, within a seemingly homogeneous subclass, individual cancers contain diverse tumour cell populations that vary in important cancer-specific traits such as clonogenicity and invasive potential. Differences that exist between and within a given tumour type have hampered...

A Multifaceted Battle Against Cancer

Cancer is the second leading cause of death in the United States [1]. As of early 2014, there were approximately 14.5 million Americans living with a history of cancer. There are also 1.6 million new cases of cancer estimated to arise in 2015 [2]. While cancer is often generalized by the definition of abnormal cell growth and invasion, it is, in fact, a group of highly heterogeneous diseases. W...

Vascular calcification: pathobiology of a multifaceted disease.

Most individuals aged 60 years have progressively enlarging deposits of calcium mineral in their major arteries.1 This vascular calcification reduces aortic and arterial elastance, which impairs cardiovascular hemodynamics, resulting in substantial morbidity and mortality2–4 in the form of hypertension, aortic stenosis, cardiac hypertrophy, myocardial and lower-limb ischemia, congestive heart f...

Multifaceted therapeutic approaches for a multigenic disease.

Diabetes is a severe chronic disease that affects approximately 200 million individuals worldwide, with extremely debilitating effects and considerably high health care costs. The two major classes of diabetes, known as type 1 (previously known as insulin-dependent or juvenile-onset diabetes) and type 2 (non-insulin-dependent diabetes), share common symptoms such as hyperglycemia and the develo...